Module 3: TRANSPORT ACROSS CELL MEMBRANES

Lecture 9: Questions

  1. Where are the target cells of diphtherotoxin located?
    1. The throat
    2. The skin
    3. The skeletal muscles
    4. The lungs
    5. The heart and nervous system
  2. What does the A in AB toxin stand for?
    1. Active      
    2. Agglutination       
    3. Adhesion  
    4. Accumulation                   
    5. None of these is correct.
  3. Which bacterium produces the hemolysin streptolysin?
    1. S. pyogenes          
    2. S. aureus  
    3. C. diphteriae                    
    4. C. botulinum                    
    5. C. tetani
  4. Which toxin contains LPS and triggers fever?
    1. Endotoxin
    2. Exotoxin  
    3. Both                     
    4. None
  5. CDCs regonize:
    1. Cholesterol as a receptor
    2. Carbohydrates moieties as a receptor
    3. Glycolipids receptor
    4. Glycoproteins
  6. How the toxins enter into the cell?
  7. What are macromolecular syringes?
  8. What are the functions of A- and B-fragments in A/B toxin for the entry of toxin into the cell?
  9. What are the two mechanisms that are used by pore forming toxins for the formation of pores in the cell membrane? Explain with an example.

References:

  1. Bacterial Protein Toxins; Kenneth Todar
  2. Blandine Geny and Michel R. Popoff (2006); Bacterial protein toxins and lipids: pore formation or toxin entry into cells, Biol. Cell 98, 667–678
  3. K. Sandvig and B. van Deurs (2000); Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives, EMBO J. , 19(22): 5943–5950
  4. Kirsten Sandvig andS jur Olsnes (1982); Entry of the Toxic Proteins Abrin, Modeccin, Ricin, and Diphtheria Toxin into Cells, The journal of biologiccahle mistry Vol. 257, No. 13, Issue of July 10, pp. 7495-7503
  5. Steven R. Blanke (2006); Portals and Pathways: Principles of Bacterial Toxin Entry into Host Cells, Volume 1, Number 1, Microbe Y 27