2.3.8 Deprotection of Functional Groups

The benzyl ethers, N-Cbz (Cbz = carboxy benzyl), and thioketal groups could be removed by reaction with molecular hydrogen and Pd or nickel catalyst (Scheme 10). The benzyl ethers and N-Cbz are deprotected by Pd-catalyst and molecular hydrogen whereas the thioketal groups are reduced to the corresponding alkanes when treated with Raney nickel and molecular hydrogen.

Scheme 10