Module 11 : Transition Metal Catalysis

Lecture 28: Titanium Catalysts


The same transformation can also be accomplished with Petasis reagent that can methylenate ketones, aldehydes and esters on thermolysis at 60°C (Scheme 5).


Scheme 5

Examples:

M. Cortes, J. A. Valderrama, M. Cuellar, V. Armstrong, M. Preite, J. Nat. Prod. 2001 , 64 , 348.

N. A. Petasis, M. A. Patane, Tetrahedron Lett. 1990 , 31 , 6799