Questions:

1. The functional mechanism of P-class ion  pumps is ............... by the ATP.
2. V-class pumps pumps exclusively ...................
3. Substance concentration + electric potential = ............................. which determines the energetically favorable direction of transport a charged molecule across a membrane.
4. Differentiate among Transporters, pumps and channels.
5. Is calcium pump and ATP dependent proton pump are same?
6. Describe ABC (ATP binding cassettes) superfamily.
7. Differentiate between V class proton pump and P-class ion pumps.
8. What are F-class ion pumps? How do they differ from the other classes of ion pumps?
9. What is the main function of a V-class proton pump?
10. Give atleast three examples of ATP-binding cassettes.
11. Give a brief overview of the structural organization of the ABC transport proteins.

 

References:

1. M. J. Schnitzer (2001); Molecular motor: Doing a rotary two-step; Nature410:878, and P. D. Boyer, 1999, Nature402:247.
2. M. Lodish (2003); Molecular cell biology: Chapter 7 Transport of ions and small molecules across cell membranes, 5th edition
3. M. Lodish (2003); Molecular cell biology: Chapter 8 Cellular energetic, 5th edition
4. Nishi, T., and M. Forgac. (2002); The vacuolar (H⁺)-ATPases— nature's most versatile proton pumps; Nature. Rev. Mol. Cell Biol.
5. Toyoshima, C., M. Nakasako, H. Nomura, and H. Ogawa (2000); Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution; Nature405:647–655.