Lecture 9

 

Lecture 10

 

Lecture 11

Primary, secondary and tertiary amines can be distinguished using Hinsberg test. The following reactions occur in this test.

a.  Primary Amines react with benzenesulfonyl chloride to give sulphonamides which have acidic amide hydrogen that is abstracted by sodium hydroxide to form a salt that dissolves but can be precipitated by acidification.

b.  Secondary amines react with benzenesulfonyl chloride to give sulphonamides which do not have acidic amide hydrogen. They are thus not soluble in the basic solution and remains insoluble on acidification.

c.  Tertiary amines do not react with benzenesulfonyl chloride but on acidification may form a salt (on long standing) which then dissolves.