Synthesis of Primary Amines
The reaction of chloramines with organomagnesium halides gives primary amines (Scheme 15).
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Scheme 15 |
Synthesis of Deutrated Hydrocarbons
Deutrated hydrocarbons can be synthesized by the reaction of organomagnesium halides with D2O (Scheme 16).
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Scheme 16 |
There are several reactions employing organomagnesium halides that have their own names
Benary Reaction It provides an effective method for the synthesis of α,β -unsaturated carbonyl compounds from β -( N,N -dialkylamino)-vinyl ketone and Grignard reagent by 1,4-addition followed by hydrolysis and elimination of the dialkylated amine. |
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Bodrous Reaction This reaction provides a method for the preparation of substituted amides from aliphatic or aromatic esters and an aminomaganesium halide which can be obtained from a primary or secondary amine and Grignard reagent at room temperature. |
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Bouveault Reaction Primary alkyl halide can be converted into aldehydes with an additional carbon via the formation of Grignard reagent followed by reaction with N,N -disubstituted formamide and hydrolysis. |
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Dzhemilev Reaction It involves the reaction of alkenes with Grignard reagent to give alkyl magnesium halide in the presence of Cp2ZrCl2 . This method had found wide application in organic and organometallic synthesis. |
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Kulinkovich Reaction The reaction of esters with dialkyldialkoxytitanium reagents, generated in situ from Grignard reagents bearing hydrogen in β -position and titanium(IV) alkoxides such as titanium isopropoxide , gives cyclopropanols. |
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