Figure 3.7: Mechanism of Bacterial cell wall synthesis.

Figure 3.8: Mechanism of Bacterial transpeptidase inhibition by penicilin-an enzyme substrate analogue.

The sulfonamide inhibitors of dihydropteroate synthase are another example. The sulfonamides are structural analogues of p-aminobenzoic acid, the substrate of dihydropteroate synthase, and act as competitive inhibitors of PABA.

Figure 3.9: Mechanism of action of antibacterial sulphonamide drugs as PABA analogue.