10.2.4 Hydroxyalkylation Reaction

The readily available cinchonidine (CD) and cinchonine (CN) can be used for the catalysis of the hydroxyalkylation of heteroaromatics. For example, the hydroxyalkylation of indoles with ethyl-3,3,3-trifluropyruvate occurs to afford corresponding 3-substituted products in high yields and ee values (Scheme 14) .