The synthesis of trifluoromethyl-substituted 2-isoxazolines can be accomplished by a domino Michael–cyclization–dehydration reaction of hydroxylamine (NH₂OH) with a range of (E)- trifluoromethylated enone derivatives in the presence of N -3,5-bis(trifluoromethyl benzyl) quinidinium bromide L6 as a chiral phase transfer catalyst (Scheme 9).

Scheme 9. Synthesis of Trifluoromethyl Substituted 2-Isoxazolines

10.2.2 Aldol Reaction

The cross-aldol reaction between enolizable aldehydes and α -ketophosphonates can be achieved using 9-amino-9-deoxy- epi -quinine L7 (Scheme 10). The reaction works especially well with acetaldehyde, which is a tough substrate for organocatalyzed cross-aldol reaction.

Scheme 10

10.2.3 Henry Reaction

Henry reaction is a classical carbon-carbon bond forming reaction in organic synthesis. Aryl aldehydes react with nitromethane in the presence of 6'-thioureasubstituted cinchona alkaloid L8 with high enantioselectivity (Scheme 11). Hydrogen-bond donor at the C6′ of L8 has been found to induce preferential formation of one enantiomer.

Scheme 11