Module 4: Formation of Aliphatic Carbon-Nitrogen Bonds

Lecture 12 : Carbon-Nitrogen Bonds Formation - III

The products have two main synthetic applications. First, several heterocyclic syntheses are performed by reducing β -keto oximes in the presence of compounds with which the products can proceed reaction to give cyclized products such as pyrroles.

Second, the oxime is hydrolyzed into a carbonyl group.

4.5.2 Nitration

Compounds generate enolate react with alkyl nitrate by base-catalyzed procedure. The reaction pathway is similar to that of the base-catalyzed nitrosation process.