Module 4: Formation of Aliphatic Carbon-Nitrogen Bonds

Lecture 11 : Carbon-Nitrogen Bonds Formation - II

 

Examples:

4.3.1.4 The Strecker Synthesis

The condensation of an aldehyde with amine gives imine that can undergo reaction with cyanide ion in situ to give an α -aminonitrile which on hydrolysis gives α -amino acid. This process constitutes a useful method for α -amino acid synthesis. Asymmetric version has also been explored.

Mechanism