Figure 37.2: Regulation of Kreb Cycle.

Similarly, Protein metabolism shares intermediate at α-ketoglutarate, oxaloacetate. As a result, kreb cycle can allosterically or through product inhibition regulates other metabolic pathways. In addition, it can redistribute intermediates between metabolic pathways and hence help in conversion of sugar to protein, lipid or vice-versa.  

2. Role in Evolution- Kreb Cycle is directly associated with running of electron transport chain and hence depends on availability of oxygen. Development of kreb cycle has evolved the organisms to adopt into the high oxygen environment.