During termination release factors (RF) are involved. when UAA or UAG is in the A site, RF1 binds to the ribosome. when UAA or UGA is in the A site, RF2 binds to the ribosome. RF3 is a  type of GTPase which main function is to catalyse the release process, through GTP binding and hydrolysis.

1. Release factor (RF1) or Release factor (RF2) binds to the ribosome nearly to the A site.
2.Polypeptide chain are released from the ribosome by the peptidyl transferase complex, peptidyl transferase complex transfer the carboxy terminal residue of polypeptide  chain from t-RNA of P site to water molecule.
3. Now the release factors ( RF )and GDP released, and t RNA also freed.
4. Now 70S ribosome is unstable due the presence of initiation factors IF3 and IF1 and  ribosome recycling factors. as a result,  70S ribosome disrupts into 30S and 50S subunits and prepared for initiation. The sequential events of termination are shown in Figure 30.13. It occurs as follows:

Figure 30.13 :Structure of 70s Ribosome