Module 1: Introduction to Enediyne Class of Natural Products

Lecture 4 : Biological Properties and Mechanisms of Action of Naturally Occurring Enediynes

Below are few examples of DNA cleavage shown by natural enediynes (Scheme 6-11).

Scheme 6. Mechanism of DNA cleavage by Calicheamicin

Scheme 7.  Mechanism of DNA cleavage by Calicheamicin

 

Scheme 8. Mechanism of biological action of dynemicin A.

Scheme 9.  Mechanism of DNA cleavage by Neocarzinostatin (zinostatin).

Scheme 10.  Proposed mechanism of action of the kedarcidin chromophore.

Scheme 11.  Mechanism of biological action of dynemicin A.