Furthermore, the construction of cis -cyclopentanones from diazoester can be achieved via exclusive insertion (Scheme 7). In addition, the construction of disubstituted cis -indane can be accomplished with 85% yield and 92% ee (Scheme 8). These examples illustrate that the choice of the reaction conditions and catalysts for carbenoid transformation are crucial for selectivity.

Scheme 7

Scheme 8