Module 3 : Organometallic Reagents

Lecture 24 : Ullman Reaction

    

Examples:

M. Feuerstein, H. Doucet, M. Santelli, Tetrahedron Lett. 2004, 45, 1603.

D. L. Comins, A. L. Williams, Org. Lett. 2001, 3, 3217.

W. R. Goundry, J. E. Baldwin, V. Lee, Tetrahedron 2003, 59, 1719.

H.-F. Chow, C.-W. Wan, K.-H. Low, Y.-Y. Yeung, J. Org. Chem. 2001, 66, 1910.


3.3.7 Castro-Stephens Coupling

The coupling of terminal alkynes and aryl halides using copper(I) salt is called Castro-Stephens coupling (Scheme 7).

Proposed Mechanism