Examples:
M. Feuerstein, H. Doucet, M. Santelli, Tetrahedron Lett. 2004, 45, 1603. |
D. L. Comins, A. L. Williams, Org. Lett. 2001, 3, 3217. |
W. R. Goundry, J. E. Baldwin, V. Lee, Tetrahedron 2003, 59, 1719. |
H.-F. Chow, C.-W. Wan, K.-H. Low, Y.-Y. Yeung, J. Org. Chem. 2001, 66, 1910. |
3.3.7 Castro-Stephens Coupling
The coupling of terminal alkynes and aryl halides using copper(I) salt is called Castro-Stephens coupling (Scheme 7).
Proposed Mechanism |