2.4.4. Meerwein-Ponndorf-Verley Reduction
The reduction of aldehydes and ketones to the corresponding alcohols with aluminum isopropoxide [Al(OiPr)3] in the presence of 2-propanol (reverse of the Oppenauer Oxidation) is called Meerwein-Ponndorf-Verley reduction (Scheme 9).
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Mechanism
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Scheme 9 |
Examples:
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T. K. Shing, C. M. Lee, H. Y. Lo, Tetrahedron Lett. 2001, 42, 8361. |
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E. J. Campbell, H. Zhou, S. T. Nguyen, Org. Lett. 2001, 3, 2391. |