Module 5 : Electrophilic Aromatic Substitution

Lecture 14 : Electrophilic Aromatic Substitution - II

5.2.8 Houben-Hoesch Reaction

This reaction refers the acylation of phenols using nitrile, hydrochloric acid and Lewis acid.

Mechanism

5.2.9 Houben-Fischer Synthesis

Base hydrolysis of t richloromethyl aryl ketimines gives aromatic nitriles, while acid hydrolysis leads to the formation of ketones.

Mechanism