Module 3 : Organometallic Reagents

Lecture 6 : Organolithium Reagents

    

Examples:

3.3.7.3 Peterson Reaction

The addition of a α -silylcarbanion to a carbonyl compound leads to the formation alkene by elimination of lithiumtrimethylsilanoate (Scheme 18).

Scheme 18

Examples:


3.3.7.4 Ramberg-Backlund-Reaction

α -Halogensulfone reacts with strong base to give an alkene (Scheme 19).

Scheme 19

3.3.7.4 Shapiro Reaction

Decomposition of a p -tosylhydrazone with two equiv of a strong base (generally methyllithium) gives alkene or vinyl lithium compounds (Scheme 20).

Scheme 20