10.1.5 Kabachnik-Fields Reaction

The three-component reaction of a carbonyl, an amine and a hydrophosphoryl compound leads to the formation of α-aminophosphonates which is very important in drug discovery research for generating peptidomimetic compounds (Scheme 11).

 

Scheme 11

10.1.6 The Photo-Arbuzov Reaction

The direct UV irradiation of phosphite can give phosphonate in moderate to good yield (Scheme 12). The reactions of both acyclic and cyclic phosphites have been explored.

Scheme 12

Examples