Examples

 

10.1.3 Arbuzov Reaction (Michaelis-Arbuzov Reaction)

It is an effective method for the synthesis of an alkyl phosphonate from a trialkyl phosphate and an alkyl halide (Scheme 7-8). The reaction finds wide applications in the synthesis of phosphonate esters which are used in the Horner-Emmons Reaction.

Scheme 7

Mechanism

Scheme 8

 

10.1.4 Michaelis Reaction (Michaelis-Becker Reaction)

It is an alternative method for the synthesis of alkyl phosphonate esters (Scheme 9-10). The yield of the process is usually less compared to the above mentioned Michaelis-Arbuzov reaction.

Scheme 9

Mechanism

Scheme 10