Module 1: Formation of Aliphatic Carbon-Carbon Bonds: Base Catalyzed Reactions

Lecture 1 : Base Catalyzed Reactions - I

1.2.1.3 The Perkin Reaction

This process consists of the condensation of an acid anhydride with an aromatic aldehyde using carboxylate ion (Scheme 9).

Mechanism

Scheme 9

1.2.1.4 The Stobbe Condensation

The Stobbe condensation leads to attachment of three carbon chain to a ketonic carbon atom (Scheme 10).

Mechanism

Scheme 10

 

Examples: