Asymmetric version of this reaction has also been well explored. For examples, chiral auxiliaries and chiral catalysts have been used as chiral source for asymmetric aldol reactions (Scheme 7).

Scheme 7

Examples:

1.2.1.2 The Reformatsky Reaction

The enolate generated from an a -bromo ester with zinc reacts with an aldehyde or ketone to give an aldol-type product in diethyl ether (Scheme 8).