Figure 27.2 Schematic representation of rhabdovirus replication cycle:

 

27.3 Important Rhabdoviruses

27.3.1 Vesicular stomatitis virus

Vesicle means blister and stomatitis means inflammation of oral mucous membrane. Vesicular stomatitis virus (VSV) is a disease of various animal species including cattle, horse, sheep and pig. Animals develop the lesions in the feet and mouth similar to that of foot and mouth disease. The VSV can replicate in a variety of cell lines. Most of our understanding regarding the rhabdovirus replication and transcription came from the study of VSV.

 

27.3.2 Bovine Ephemeral fever virus

It is an arthropod transmitted disease of cattle and buffalo characterized by biphasic or polyphasic fever, depression, diarrhea, and loss of appetite. The disease is also called as 3-day stiff-sickness . The virus causes inflammation and injury to the inner lining of the endothelial blood vessels.

 

27.3.3 Infectious hematopoietic necrosis virus

It is a disease of salmonid fishes. The virus is associated with significant economic losses to the countries producing salmon in large quantity. Infection is characterized by darkened body colour, pale gills, distension of abdomen due to accumulation of fluid, and hemorrhages around fins.