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31.1 Immunity to allograft

Polymorphic genes called histocompatibility genes are responsible for the recognition of foreign transplant cells, and are very diverse among the individuals of same species. Some of the basic rules of transplantation are as follows

•  Cells and organ transplanted between genetically identical individuals are not rejected.

•  Cells and organ transplanted between two genetically non identical or different individuals are always rejected.

•  The offspring of two different inbred animals usually do not reject the organ or tissue from either of the parents.

•  The parents of an offspring belonging to two different inbred strains usually reject the graft taken from the offspring.

Figure 31.1 Genetics of graft rejection in mice: