Module 4 : A Case Study using Molecular Dynamics with NAMD

Lecture 13 : Nervous System (Part-I)

The Synapse and Synaptic transmission
The area of functional contact between two neurons for transmission of information is known as synapse. In a synapse, membrane of telodendria is called as pre-synaptic membrane and membrane of dendron of other neuron is known as post-synaptic membrane and the space between these two membranes is known as synaptic cleft.
When action potential develops in pre-synaptic membrane. It becomes permeable for calcium ions and Ca2+ enters in pre-synaptic membrane. When vesicles burst by the stimulation of Ca2+ it release acetyl choline (Ach). Then Ach reaches the post synaptic membrane via synaptic cleft and bind with receptors, which develop excitatory post synaptic potential. The process of synaptic transmission is shown in Figure 13.5.  

 

Figure 13.5: Transmission of nerve impulse at a synapse.