·
5.2.2 Synthesis of Esters
The synthesis of esters from carboxylic acids and alcohols can be accomplished in the presence of DCC in CH2 Cl2 solvent at ambient conditions. This reaction is called Steglich esterification and usually for the sterically hindered substrates (Scheme 4).
Scheme 4
Mechanism
The carboxylic acid proceeds reaction with DCC to afford activated acylating agent that undergoes reaction with the alcohol (Scheme 5).
Scheme 5
5.2.3 Synthesis of Ethers and Thioethers
Phenols and thiophenols can be reacted with alcohols to give ethers in the presence of DCC (Scheme 5).
Scheme 6