2.1.1.4 Reduction of Acids
The acids are often reduced with LAH to prepare the corresponding alcohols (Scheme 5). The other comparable method for reduction of acid is using BH3 as a reducing agent. The three hydride ions are consumed for reducing one acid group.
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Scheme 5 |
2.1.1.5 Reduction of Esters and Amides
The esters and amides are reduced to the corresponding alcohols and amines, respectively,
when treated with LAH (Scheme 6). Each molecule of ester or amides consumes two molecules of hydride ions.
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Scheme 6 |
2.1.1.6 Reduction of Azides, Nitriles and Nitro Compounds
The azides, nitriles and nitro compounds are reduced to the corresponding amines in presence of LAH (Scheme 7). The aromatic nitro compounds do not give the desired amines.
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Scheme 7 |