High Pressure Synthesis

Approach : By increasing the pressure it allows you to explore regions of the phase diagram not accessible at atmospheric pressure.

Advantages : Often leads to formation of compounds which cannot be formed using any other technique. The presence of high non-metal partial pressures (i.e. high O₂ partial pressure) can be used to stabilize cations in unusually high oxidation states.

Disadvantages : High pressure synthesis equipment tends to be large and expensive. Product volume is often times so small that characterization becomes difficult, and practical application can be impractical.