Module 4 : Bioorganic Chemistry of Nucleic Acids

Lecture 4 : Stability, Properties, and Functions of DNA - II

4.15.2.1. TRANSCRIPTION

4.15.2.2. TRANSLATION

The message on DNA that has been translated to mRNA:

  1. Degenerate: more than one three base codon can code for the same amino acid
  2. Specific: each codon specifies a particular amino acid
  3. Non-overlapping and comma less:
    • None of the bases are shared between consecutive codons
    • No noncoding bases appear in the base sequence
  4. Universal: all organisms use the same code
  5. All 64 codons have meaning
    • 61 code for amino acids
    • Three code for the “stop” signal
  6. Multiple codes for an amino acid tend to have two bases in common
    • CUU, CUC, CUA, CUG code for leucine
    • Makes the code mutation resistant
  7. Codons are written in a  5'     3' sequence

4.15.2.2.1. The Genetic Code