Figure 28.5: Schematic diagram of bead mill disruption

2. High Pressure Homogenizer- A high pressure homogenizer consists of a high pressure positive displacement pump connected to the an adjustable discharge valve with a restricted opening (Figure 28.6). The cell suspension is send into the homogenizer through a small homogenizing valve at a very high pressure (200-1000 atmospheric pressure). Cell passing through a small valve experience stress developed within the fluid and as result it get disrupted. The stress developed is expressed as dynamic pressre Ps and it is expressed as-