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Figure 33.1 Difference between a normal and hemophilic condition:

When injury occurs and the blood vessel starts leaking out blood then the attachment of platelets at the site of injury enables the vasoconstriction i.e. narrowing of the blood vessel to prevent blood loss. The activation of clotting factors is initiated. Under normal circumstances the blood clotting involves the strong platelet plug formation due to the factor VIII. It stabilizes the fibrin clot and seals the injured tissue thus, stops bleeding. Fibrinolysis is the process used to clear the clot after wound recovery. In haemophilic condition the factor VIII is absent that causes the formation of weak platelet plug. Thus, the wound is not properly sealed hence continuous loss of blood due to leakage through loose fibrin clot takes place. Excessive bleeding may cause death of the individual.