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Table 24.1 Prodrug system used experimentally:

Methods of Suicide Gene Delivery include:

• •  Non viral Transfection

•  Retrovirus mediated Suicide Gene delivery

•  Adenoviral Gene transfer

•  Oncolytic viruses

•  Other viral vectors being explored for suicide gene delivery includes Adeno associated virus, Herpes Simplex Virus, Human Papilloma Virus, Vaccinia virus, avipox virus and baculovirus.

Many studies have demonstrated that tumor eradication takes place even on transducing only 10% of the tumor mass, probably due to a very effective bystander effect.