36.2.3  Multiple sclerosis

It is most prevalent in young adults characterized with neurologic symptoms especially inflammation of central nervous system and disorder in nerve conduction. Myelin acts as a self antigen and there is a regular lesion formation in the patient. B cell depletion is the approved treatment in some patients.

 

36.2.4  Type I Diabetes Mellitus

The disease occurs due to defective insulin production resulting in hyperglycemia (more glucose in blood) and ketoacidosis ( high concentrations of ketone bodies in blood ). In such individuals hormone replacement therapy is constantly required to compensate the deficiency of insulin in their body.

 

36.2.5 Inflammatory bowel disease

In this disease damage to intestinal wall occurs because of T-cell mediated inflammation. It occurs in two forms, namely Crohn's disease and ulcerative colitis . Therapeutic approaches include antibodies against p40 chain of IL-12 and IL-23, TNF and IL-17.