26.1 Function of Th17 cells

After differentiation of naïve T cells into Th17 effector cells, they start secreting IL-17 and IL-22. IL-17 is a unique cytokine that do not have any homologue in the body. IL-17 stimulates the production of chemokines, TNF, IL-1, IL-6, and granulocyte-colony stimulating factors (G-CSF) which take part in inflammatory reactions. In addition, it is also involved in the production of defensins from the epithelial surface which in turn acts as a barrier for the invading pathogens. IL-22 is a relatively new interleukin and its function is not well established. However IL-22 is known to maintain the epithelial integrity, increase barrier function and involve in the repair activity following inflammation.

Figure 26.1 Functions of Th17 cells: