7-2.4 Metabolic Engineering in Microorganisms for Production of Antibiotics:

• Metabolic engineering considers metabolic and cellular system as an entity and accordingly allows manipulation of the system with consideration of the efficiency of the overall bioprocess, which distinguishes itself from simple genetic engineering.
  
  
• It allows defined engineering of the cell, thus avoiding unnecessary changes to the cell and allowing further engineering if necessary.
  
  
• The table listed below is the compilation of different drug precursors and their host organisms and how they are genetically manipulated for the same.

Table 7-2.4 Various synthetic drug derivatives, their host and modification strategy