Table 6-4.4.1.1: Human therapeutic proteins in transgenic animals
Animal |
Drug/protein |
Use |
sheep |
alpha1 anti trypsin |
deficiency leads to emphysema |
sheep |
CFTR (Cystic fibrosis transmembrane conductance regulator) |
treatment of cystic fibrosis |
sheep |
tissue plasminogen activator |
treatment of thrombosis |
sheep |
factor VIII & IX (blood clotting protein) |
treatment of hemophilia |
sheep |
fibrinogen |
treatment of wound healing |
pig |
tissue plasminogen activator |
treatment of thrombosis |
pig |
factor VIII, IX |
treatment of hemophilia |
goat |
human protein C |
treatment of thrombosis |
goat |
antithrombin 3 |
treatment of thrombosis |
goat |
glutamic acid decarboxylase |
treatment of type 1 diabetes |
6-4.4.1.2 Antibody production using transgenic animals:
Mammary glands of several transgenic animals are targeted for specific production of monoclonal antibodies specific for various diseases. Transgenic goats and cattle are developed for such application.