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Chemistry and Biochemistry
Bio-Organic Chemistry of Natural Enediyne Anticancer Antibiotics (Web)
Syllabus
Co-ordinated by :
IIT Guwahati
Available from :
2013-09-03
Lec :
1
Modules / Lectures
Introduction to Enediyne Class of Natural Products
History of Discovery of Enediynes and History of Cancer
Microbial Drug Discovery and Isolation of Enediynes
Molecular Structures of Enediynes
Biological Properties and Mechanisms of Action of Naturally Occurring Enediynes
The Bergman Cyclisation Reaction-Part-1
The Bergman Cyclisation Reaction-Part-2
The Bergman Cyclisation Reaction-Part-3
The Bergman Cyclisation Reaction-Part-4
The Myers-Saito Cyclisation Reaction-Part-1
The Myers-Saito Cyclisation Reaction-Part-2
Selected References I
Assignment I
Synthesis/Biosynthesis of Enediynes Class of Natural Products
Classifications of Natural Enediynes
Mechanism of DNA Cleavage by Each Class
Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Neocarzinostatin)- Part-1
Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Calicheamicin)-Part-2
Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Calicheamicin)-Part-3
Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Dynemicin A)-Part-4
Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of N1999A2)-Part-5
Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Kedarcidin Chromophore-Hirama’s Approach)-Part-6
Chemical Synthesis of a Few Members of Enediynes Natural Products (Synthesis of Kedarcidin Chromophore-Myers’ Approach)-Part-7
Biosynthesis of a Few Members of Natural Enediynes (Synthesis of Maduropeptin)-Part-8
Biosynthesis of a Few Members of Natural Enediynes-Part-1
Biosynthesis of a Few Members of Natural Enediynes (General Biosynthesis)-Part-2
Biosynthesis of a Few Members of Natural Enediynes (Biosynthesis of C-1027)-Part-3
Biosynthesis of a Few Members of Natural Enediynes (Biosynthesis of Neocarzinostatin)-Part-4
Biosynthesis of a Few Members of Natural Enediynes (Biosynthesis of Maduropeptin)-Part-5
Biosynthesis of a Few Members of Natural Enediynes (Biosynthesis of 10-Membered Enediynes , Calicheamicin ?1I)-Part-6
Selected References II
Assignment II
Designed Enediyne Model Systems
Introduction to Structural Features of Enedynes and Factors Affecting the Reactivity of Enediynes
Molecular Design of Enediyne Models (Acyclic Enediynes- Structural Representation) Part-1
Molecular Design of Enediyne Models (Acyclic Enediynes-Representative Examples)-Part-2
Molecular Design of Enediyne Models (Cyclic Enediynes- Structural Representation)-Part-3
Molecular Design of Enediyne Models (Cyclic Enediynes-Representative Examples)-Part-4
Various Synthetic Approaches to Acyclic/Cyclic Enediynes
Various Synthetic Aprroaches to Cyclic Enediynes-Part-1
Various Synthetic Aprroaches to Cyclic Enediynes-Part-2
Synthesis of Dienediyne Core of NCS chromophore
?-Lactam as a Molecular Lock of Enediyne: Synthesis of ?-Lactam Fused Enediynes
Enediynes with pH-Based Triggering Devices (Category 1-3)-Part-1
Enediynes with pH-Based Triggering Devices (Category 4-5)-Part-2
Photoswitchable Enediynes (Category 1-2)-Part-1
Photoswitchable Enediynes (Category 3-6)-Part-2
Biological Actions of Some Synthetic Models
Enediyne as a Scaffold for Peptidomimetics
Enediyne as Peptide Cleaving Agent
Selected References III
Assignment III
Applications of Enediyne Antitumor Antibiotics
Defining Cancer and Its Various Type-Part-1
Defining Cancer and Its Various Type- Part-2 and Cancer-Combination Therapies
Therapeutic Applications of Enediyne Antitumor Antibiotics
The Approved Enediynes for Use as Anticancer Drugs
Enediynes Under Clinical Investigation and Immunoconjugates
Antibody–Drug Conjugates
Targeted Chemotherapy
Antibody-Enediyne Conjugate under Clinical Investigation and Future Prospect and Recent Advances in Enediyne Research
Selected References IV
Assignment IV
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