- Conformation of molecule arise due to free rotations around single bond.
- Stereoisomers which can interconvert at low temperature separated by a low energy barrier of [E < 60 kJ mol-1 ]are called conformers.
- For spectroscopic analysis of conformers they should be subjected to a lower temperature which can freeze or slow down the rapid flipping between two conformers to elucidate data of particular conformer.
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- It is a permanent spatial arrangement of molecule which can only be changed by bond breaking and reforming (such as a double bond)
- Stereoisomers having high energy barrier [E >100 kJ mol-1] and stable at room temperature are called conformers.
- A configurational isomer is relatively stable and can be well elucidated at ambient temperature.
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