| Collins reagent can be prepared and isolated or generated in situ. |
- Collins reagent is the mixture of chromium trioxide with pyridine in dichloromethane.
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| Isolation of reagent often leads to improved yields. |
| It is used to selectively oxidize primary alcohols to aldehyde, and will tolerate many other functional groups in the molecule. |
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| It can be used as an alternative to Jones reagent and PCC in oxidation of secondary alcohols. Moreover, Collins reagent is especially useful for oxidations of acid sensitive compounds. |
| This complex is both difficult and dangerous to prepare, as it is very hygroscopic and can inflame during its preparation. |
| It is required to be used in a sixfold excess in order to complete the reaction. |
| One of the steps in the synthesis of prostaglandin F2α employs Collin’s reagent as oxidant. |
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Corey E J, JACS, 1969, 91, 5675 |
