Table 1: Few Gene, Genename, corresponding SNPs and their class.

Gene	Gene Name	SNP	SNP Class
APOE	Apolipoprotein E	rs4966978	NonSyn intron
USF1	Upstream transcription factor 1	Haplotype across USF1	NA
GATA2	GATA binding Protein 2	rs2713604	5'UTR
LTA4H	Leucotreine A4 hydrolase	Haplotype K	NA
PSMA6	Proteasome subunit alpha 6	rs3850641	Intron
GJA4	Gap junction alpha 1	rs1764391	NonSyn intron

Types of SNPs

Non-coding SNPs: They can be 5'-UTR (Untranslated Regions), 3'-UTR, introns, intergenic regions and pseudogenes occurring in the genome. The regulation machinery of these non-coding SNPs includes splicing, transcriptional regulation and translational regulation.

Coding SNPs: These types of SNPs are also called as synonymous SNPs (due to third position variation). Other coding SNPs are replacement SNPs which cause change in amino acid, therefore categorized again in two types: 1) Functional SNPs (acceptable amino acid replacement) and 2) Non-functional SNPs (traits & diseases)

Methods of analysis of SNPs

Analytical methods to discover novel SNPs and detect known SNPs include