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Explain how mass spectrometry is can be used for study of post translational?

Hint:

√  Addition or removal of phosphate groups or acetyl groups results in mass changes of 80 Da) and 42 Da, respectively.

√  Modification may be identified by analysis of intact protein. Further, protein may be cleaved by proteases and fragments may be analyzed to exact site of modification.

√  With this hints explain your answer.

 

 

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